Last edited by Mugor
Friday, July 24, 2020 | History

5 edition of Molecular Pathology of Type 1 Diabetes Mellitus (Current Directions in Autoimmunity) found in the catalog.

Molecular Pathology of Type 1 Diabetes Mellitus (Current Directions in Autoimmunity)

by Matthias G. Von Herrath

  • 324 Want to read
  • 29 Currently reading

Published by S. Karger Publishers (USA) .
Written in English

    Subjects:
  • Medical,
  • Medical / Nursing,
  • Diseases - General,
  • Medical / Immunology,
  • Pathology,
  • Autoimmune Diseases,
  • Diabetes,
  • Diabetes Mellitus, Insulin-Dep,
  • Diabetes Mellitus, Insulin-Dependent,
  • Immunology,
  • Molecular aspects,
  • genetics

  • The Physical Object
    FormatHardcover
    Number of Pages360
    ID Numbers
    Open LibraryOL12931297M
    ISBN 103805572409
    ISBN 109783805572408

    Current Diabetes Reviews publishes full-length/mini reviews, original research articles, drug clinical trial studies and guest edited issues on all the latest advances on diabetes and its related areas dedicated to clinical research e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care and therapy.. The journal is essential reading for all researchers and clinicians who. The first edition of this book gained recognition as the definitive textbook of diabetes epidemiology. The second edition builds on this success, gathering recent information on international trends and data for diabetes mellitus.

    Use: Diagnosis of Type 1 Diabetes: The presence of autoantibodies against insulin (IAA) in patients with diabetes mellitus indicates the presence of autoimmune, type 1 is advised that blood for IAA testing be drawn before insulin therapy is initiated. For the IAA result to be valid, the patient must not be insulin treated for more than 1 week. Leucine-rich αglycoprotein-1 (LRG1) was recently reported as a novel proangiogenic factor that is expressed in endothelial cells and promotes angiogenesis by modulating the transforming growth factor-βsignaling pathway. However, the pathophysiology of LRG1 in diabetic nephropathy .

    According to the American Diabetic Association (), the diagnosis of type 2 diabetes mellitus can be made after establishing one of the following: 1.) A glycosolated hemoglobin, or hemoglobin A1C, greater than or equal to %. 2.) A fasting plasma glucose greater than mg/dL.   Abstract. Background: A complex interplay between genetic and environmental factors contributes to disease etiology of most of the autoimmune disorders. Type 1 diabetes mellitus (T1DM) and celiac disease (CD) are polygenic autoimmune diseases that have high propensity to coexist due to shared etiological factors like genetics and clinico-pathological overlaps.


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Molecular Pathology of Type 1 Diabetes Mellitus (Current Directions in Autoimmunity) by Matthias G. Von Herrath Download PDF EPUB FB2

Molecular Pathology of Type 1 Diabetes mellitus (Current Directions in Autoimmunity, Vol. 4): Medicine & Health Science Books @ hor: M.G. von Herrath. Molecular pathology of type 1 diabetes mellitus. Basel ; New York: Karger, © (OCoLC) Online version: Molecular pathology of type 1 diabetes mellitus.

Basel ; New York: Karger, © (OCoLC) Material Type: Internet resource: Document Type: Book, Internet Resource: All Authors / Contributors: Matthias G Von Herrath. Evidence from epidemiological and histopathologic studies in humans with autoimmune type 1 (insulin-dependent) diabetes suggests that beta-cell destruction within the islets of Langerhans progresses through a number of stages.

In this review we draw on recent experimental evidence in an attempt to define the molecular pathology of these by:   Pathophysiology of Type 1 Diabetes condition is by large characterized by a deficiency of insulin hormone. For effective understanding, medicine has had pathophysiology of Type 1 Diabetes mellitus made easy by grouping into three are an autoimmune mechanism, genetic considerations, environmental factors.

This chapter describes the current understanding of the syndrome of DM in the context of molecular biology of glucose homeostasis, role of insulin secretion and resistance, genetic/genomic and molecular pathology, relationship with overweight and obesity, the spectrum of clinical manifestations, pharmacotherapy, and supportive treatment strategies for the management of : Dhavendra Kumar, Dhavendra Kumar, Dhavendra Kumar.

Susceptibility to type 1 diabetes is associated with two combinations of DQA1 and DQB1 alleles, namely: DQA1*DQB1* and DQA1*DQB1*, which encode the HLA-DQ2 and HLA-DQ8 molecules, respectively.

Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease in which destruction of pancreatic β-cells causes insulin deficiency which leads to hyperglycemia and a tendency to ketoacidosis.1Excesses glucose levels must be managed by exogenous insulin injections several times a day.2Patients with T1D constitute % of all people with diabetes, the remainder having type 2 diabetes, monogenic forms of diabetes, or diabetes.

Pathogenesis of type 1 diabetes mellitus Type 1 diabetes mellitus is a chronic autoimmune disease associated with selective destruction of insulin- producing pancreatic β-cells (Figure 1). The onset of clinical disease represents the end stage of β-cell destruction leading to type 1 diabetes mellitus.

Gestational diabetes mellitus (GDM) is a serious pregnancy complication, in which women without previously diagnosed diabetes develop chronic hyperglycemia during gestation. In most cases, this hyperglycemia is the result of impaired glucose tolerance due to pancreatic β-cell dysfunction on a background of chronic insulin resistance.

Type 1 and type 2 diabetes mellitus (DM) are chronic diseases that affect nearly million people worldwide, leading to poor health outcomes and high health care costs. High-throughput metabolomics screening can provide vital insight into the pathophysiological pathways of DM and help in managing its effects.

The primary aim of this study was to contribute to the understanding and management. Background and Objectives: The global epidemic of diabetes, especially type 2 (DM2), is related to lifestyle changes, obesity, and the process of population ic retinopathy (DR) is the most serious complication of the eye caused by diabetes.

The aim of this research was to assess the prevalence of diabetic retinopathy in type 1 and type 2 diabetes mellitus patients in north-east Poland. Get this from a library. Molecular pathology of type 1 diabetes mellitus. [Matthias G Von Herrath; S.

Karger (Firm);]. Type 1 Diabetes This book contains a series of up-to-date chapters that review our current knowledge of type 1 diabetes as an autoimmune disease, the problems that still remain with existing treatments, and possible solutions for the near future.

Author (s): Alan P. Escher and Alice Li Pages. Historical Model of Type 1 Diabetes Pathogenesis. It may be considered unusual to consider a period of three decades “historical.” Yet, the evolution for our understanding of the natural history and pathogenesis of type 1 diabetes has been greatly advanced by a vast number of studies aimed at validating a model (), proposed by the late Dr.

George Eisenbarth in (). Insulin-Dependent Diabetes Mellitus (IDDM) Type 1 Etiology of Type 1 Diabetes. Type 1 diabetes has been shown to be the result of an autoimmune reaction to antigens of the islet cells of the pancreas. There is a strong association between IDDM and other endocrine autoimmunities (e.g.

Addison disease). Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series focuses on diabetes as a nutritional problem and its important metabolic consequences. Fuel metabolism and dietary supply all influence the outcome of diabetes, but understanding the pathogenesis of the diabetic process is a prelude to better nutritional control.

von Herrath MG (ed): Molecular Pathology of Type 1 Diabetes Dir Autoimmun. Basel, Karger,vol 4, pp There are 2 main categories of diabetes mellitus—type 1 and type 2, which can be distinguished by a combination of features (see table General Characteristics of Types 1 and 2 Diabetes Mellitus).Terms that describe the age of onset (juvenile or adult) or type of treatment (insulin - or non– insulin-dependent) are no longer accurate because of overlap in age groups and treatments between.

Diabetes is defined as a disease in which the body has an impaired ability to either produce or respond to the hormone with type 1 diabetes have a pancreas that does not make with type 2 diabetes have cells in the body that are resistant to insulin or have a pancreas that slows or stops producing adequate insulin levels (blood glucose).

Type 1 diabetes is the result of an autoimmune reaction to proteins of the islets cells of the pancreas while type 2 diabetes is caused by a combination of genetic factors related to impaired.

The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach.People with Type 1 diabetes must use insulin injections to control their blood glucose.

Type 1 is the most common form of diabetes in people who are under but it can occur at any age. Ten percent of people with diabetes are diagnosed with Type 1. In Type 2 diabetes (adult onset diabetes), the pancreas makes insulin, but it either doesn.PIECES OF THE PUZZLE.

The general features of hyperglycemia-induced tissue damage are shown schematically in Fig. DCCT (Diabetes Control and Complications Trial) and the UKPDS (U.K.

Prospective Diabetes Study) established that hyperglycemia, shown on the far left of the figure, is the initiating cause of the diabetic tissue damage that we see clinically, shown on the far right (1,2).